Job Title

Medical Director / Senior Medical DirectorAbout Us:Eupraxia is a clinical-stage biotechnology company focused on developing locally delivered, extended-release products that have the potential to address therapeutic areas with high unmet medical need. DiffuSphere, a proprietary, polymer-based micro-sphere technology, is designed to facilitate targeted drug delivery of both existing and novel drugs. The technology is designed to support an extended duration of effect and delivery of drugs in a hyper-localized fashion, targeting only the tissues that physicians want to treat. We believe the potential for fewer adverse events may be achieved through the precision targeting and the stable and flat delivery of the active ingredient when using the DiffuSphere technology, versus the peaks and troughs seen with more traditional drug delivery methods. The precision of Eupraxia's DiffuSphere technology platform has the potential to augment and transform existing FDA-approved drugs to improve their safety, tolerability, efficacy and duration of effect. The potential uses in therapeutic areas may go beyond pain and inflammatory gastrointestinal disease, where Eupraxia currently is developing advanced treatments, also to be applicable in oncology, infectious disease and other critical disease areas.Eupraxia's EP-104GI is currently in a Phase 1b/2a trial, the RESOLVE trial, for the treatment of EoE. EP-104GI is administered as an injection into the esophageal wall, providing local delivery of drug. This is a unique treatment approach for EoE. Eupraxia also recently completed a Phase 2b clinical trial (SPRINGBOARD) of EP-104IAR for the treatment of pain due to knee osteoarthritis. The trial met its primary endpoint and three of the four secondary endpoints. In addition, Eupraxia is developing a pipeline of later and earlier-stage long-acting formulations. Potential pipeline indications include candidates for other inflammatory joint indications and oncology, each designed to improve on the activity and tolerability of currently approved drugs. For further details about Eupraxia, please visit the Company's website at: www.eupraxiapharma.com.We are looking for someone who would like to work for a fast-paced, growing company that fosters a creative spirit and integrated teamwork and who is eligible to work in Canada and the United States.Job Description: The job holder plays a critical leadership role in the design, development and implementation of clinical protocols to support the companys product strategy. Working with colleagues to ensure appropriate data collection and management, the drafting and development of final reports in compliance with appropriate standard operating procedures, regulatory and medical standards. The position serves as the clinical science expert and scientific liaison between cross-functional stakeholders including Clinical Operations, Regulatory Affairs, Biostatistics, Medical Affairs, and external collaborators to oversee the delivery of the appropriate clinical activities to deliver the required business objectives of the clinical program. Reports to: Chief Medical OfficerResponsibilities: Clinical Trial Design & ExecutionLead or co-lead the development of clinical study protocols, amendments, investigator brochures, and related documents.Collaborate with cross-functional teams to ensure robust study design aligned with program objectives and regulatory requirements.Provide ongoing scientific input and oversight during study conduct, including medical monitoring, data reviews, and protocol deviations.Be the main point of contact for the Contract Research Organization (CRO) medical and pharmacovigilance teams.Data Analysis & InterpretationLead clinical data review activities to ensure scientific integrity and consistency.Contribute to or lead the preparation of clinical study reports, regulatory documents (e.g., INDs, NDAs, BLAs), and publications.Interpret clinical data in collaboration with medical and statistical colleagues.Scientific Strategy & CommunicationServe as a subject matter expert on disease area and investigational product(s).Contribute to the development of the Clinical Development Plan (CDP).Present clinical data and strategy to internal stakeholders, advisory boards, and regulatory authorities.Support key opinion leader (KOL) engagement and contribute to scientific publications and presentations.Cross-functional CollaborationWork closely with Medical, Clinical Operations, Regulatory, Quality, Safety, and Biostatistics to ensure clinical program success.Support health authority interactions and preparation for regulatory meetings.Mentor junior clinical scientists or cross-functional partners as needed.Other ad hoc duties and assignments as requested for the overall performance of the function and the company.Requirements:MD or equivalent qualification.Physician with prior clinical experience. Background in Rheumatology, Inflammatory Diseases / Gastroenterology is an asset.Minimum of 5+ years clinical experience, in biopharma/biotech covering stages (Phase I to III).Global clinical trial exposure is an asset. Industry experience in oncology, an advantage.Strong scientific background with ability to understand and interpret complex clinical data.Ability to assimilate new science and indications quickly. Experience in writing protocols, clinical reports, and regulatory submissions.Ability to evaluate, interpret, and synthesize scientific data.Excellent communication, leadership, and project management skills.Ability to verbally present and critically discuss clinical trial data in internal and external meetings.Understanding of FDA, GCP and ICH guidelines, global regulatory agency requirements.Experience in publishing results of a clinical drug trial in a refereed journal.Experience in submitting an NDA/IND to regulatory authorities in Europe and/or US.Proven ability to work in a matrixed, cross-functional environment.Understanding of Business Practices (strategic and product marketing, and sales).Ability to understand the relationship between high business potential, medical need and development cost and timelines.Additional attributes:Ability to maintain a high level of confidentiality.Experience working with drugs with a similar mechanism of action, preferred. Specialized training in certain disciplines in clinical trial methodology such as statistics, an advantage. pharmacokinetics, or Pharmacoeconomics.Excellent communication and time management skills and possess a high level of organizational ability.Attention to detail due to various factors affecting contract entitlements.Possess troubleshooting, problem solving, and creative/innovative thought processing skills.Understand office formats and procedures.Demonstrated leadership skills and ability to document and implement processes and procedures. Self motivated and self-directed.Salary Range: CAD$260,000-340,000 annuallyWithin the posted range, individual pay is determined by job-related skills, relevant experience, education and/or training. Please note that the range details above reflect the base pay only. A bonus will be available based upon performance and remaining in post for the agreed contract duration. We also have a competitive benefits package on offer.This is an opportunity to work in a small, entrepreneurial, and highly motivating environment, with a strong emphasis on work/life balance and a supportive company culture.How to Apply:Please send your CV and cover letter to careers@eupraxiapharma.comWhile only short-listed candidates will be notified, we thank each applicant for their submission.