Job Title

About Stiris Research Stiris Research is an entrepreneurial Clinical Trial Management Company providing Phase I through IIIB full-service support to Biotechnology and Biopharmaceutical companies. We make a difference by collaborating in the life sciences to improve others lives. Work model: Remote (Canada preferred, U.S. considered) Employment type: Full-time Position Summary Stiris Research is seeking an experienced Project Manager, Clinical Operations, to lead the operational planning and delivery of clinical trials across the study lifecycle. You will be accountable for timelines, quality, budget oversight, and cross-functional coordination across internal teams, sites, sponsors, and service providers. Key Responsibilities Own the quality and timeliness of study deliverables across feasibility, start-up, site activation, recruitment, conduct, database cleaning, and close-out. Lead and coordinate cross-functional teams to deliver study milestones with clear expectations, communication, and accountability. Build and maintain strong relationships with sponsors, sites, service providers, and internal stakeholders. Track and proactively manage study timelines, KPIs, metrics, and projections, maintain risk and issue logs, and escalate risks with clear mitigation plans. Establish and run appropriate study governance (e.g., sponsor updates, internal project reviews), including clear documentation of decisions and action items. Manage resourcing needs and support team performance, onboarding, and study-specific training throughout trial delivery. Maintain oversight of study budget health, including forecasting, and proactively escalate risks or variances to support timely, informed decisions. Oversee service provider performance and deliverables, ensuring expectations, quality standards, and timelines are met, address issues promptly, and document outcomes. Assess operational performance and develop corrective and preventive action plans for site, service providers, and administrative issues. Support sponsor-specific processes, including SOP mapping and alignment activities. Support quality oversight and inspection readiness, including oversight of trial essential records (TMF/ISF) completeness and compliance with ICH-GCP and applicable requirements. Contribute to continuous improvement through lessons learned, process enhancements, and mentoring/coaching of project team members as appropriate. Required Qualifications 10+ years of experience in Clinical Operations, supporting and delivering clinical trials. 8+ years in a Clinical Project Manager (or equivalent PM) role, leading end-to-end trial execution. Strong working knowledge of ICH-GCP and applicable regulatory/quality requirements. Demonstrated experience managing sites, timelines, metrics, and budgets. Strong leadership and stakeholder management skills; able to influence, align, and drive accountability across diverse teams. Excellent organizational, analytical, and communication skills; comfortable operating under pressure and shifting priorities. Strong computer literacy (e.g., MS Word, Excel, Outlook, SharePoint, CTMS/TMF). Preferred Qualifications (Optional) Experience in Oncology and/or Rare Diseases Experience working with both Canadian and U.S. sites/sponsors. PMP certification and/or relevant life sciences degree. Compensation Salary range: CAD $130,000 $150,000 How to Apply: Please submit your CV to Allyson MacLean () with the subject line: Senior Project Manager, Clinical Operations.