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About Absci Absci is a clinical-stage biotechnology company advancing novel therapeutics using generative AI. Our Integrated Drug Creation platform combines cutting-edge AI models with a synthetic biology data engine, enabling the rapid design of innovative therapeutics that address challenging therapeutic targets. Absci is a global company headquartered in Vancouver, WA, and maintains offices in New York City, Switzerland, and Serbia. Learn more at www.absci.com or follow us on LinkedIn @absci, X @Abscibio, and YouTube. Associate Director, Pharmacology & Bioassays Location: Onsite, Vancouver, WA (HQ) About the role Absci is seeking a visionary scientific leader to join us as Associate Director, Pharmacology & Bioassays. In this pivotal role, you will spearhead a multidisciplinary team driving in vitro and ex vivo functional characterization of nextgeneration biologics, including antibodies, bispecifics, and engineered binding proteins, to advance Abscis discovery and preclinical pipeline. Associate Director, Pharmacology & Bioassays will serve as the groups primary subject matter expert (SME) in pharmacology, mechanistic biology, and functional assay strategy. They will ensure that data generated by the team is rigorous, reproducible, and directly informs program strategy from early discovery through INDenabling studies. This is a critical scientific leadership role reporting to the Head of Disease Biology and partners closely with Disease Biology, Protein Engineering, and HighThroughput Screening (HTS) functions at Absci. Key Responsibilities Scientific & Functional Leadership Lead, mentor, and develop a highperforming team focused on in vitro and ex vivo assay development, mechanistic biology, and functional pharmacology. Serve as the primary pharmacology SME on internal project teams. Provide scientific direction on assay strategies and mechanistic understanding of biologic therapeutics, including MOA, receptor pharmacology, signaling pathways, and functional readouts. Uphold strong scientific rigor, reproducibility, data quality, and interpretation standards across all team deliverables. Pharmacology & Mechanistic Biology Oversee the design, development, optimization, and execution of cellbased functional assays that evaluate potency, mechanistic activity, selectivity, and biological relevance of Abscis therapeutic candidates. Guide assay strategies supporting: Target validation and MOA elucidation Lead identification and optimization Structurefunction and functional epitope analysis Cell biology studies relevant to diseaseassociated pathways Integrate functional biology insights into quantitative pharmacology frameworks (e.g., doseresponse modeling, receptor occupancy, PK/PD translation). Program Strategy & CrossFunctional Partnership Represent the Pharmacology & Bioassays group on crossfunctional project teams, translating complex data into actionable recommendations and clear articulation of program risks. Collaborate closely with Protein Engineering, HTS, and Disease Biology to drive cohesive, milestonealigned experimental plans. Identify data gaps, propose scientifically sound solutions, and guide planning to ensure programs remain on track with the right assays and decisionmaking metrics. Support in vivo study design by developing complementary in vitro/ex vivo assays to inform MOA, PD biomarkers, and dose selection. Operational Excellence Build and maintain stateoftheart workflows and technologies relevant for cellbased and ex vivo assay systems (e.g., primary cell systems, cytokine/receptor signaling assays, flow cytometry, highcontent imaging). Implement best practices for assay robustness, statistical rigor, documentation, and reproducibility. Manage team resources, timelines, and workload across multiple programs in a dynamic, fastpaced environment. Evaluate and oversee external collaborations, including CROs and academic groups, as needed. Qualifications Education & Experience PhD in Pharmacology, Cell Biology, Biochemistry, Immunology, or a related discipline with 57+ years of industry experience, or an equivalent combination of advanced degree and experience. Demonstrated track record of scientific leadership and team development. Proven experience supporting or leading antibody drug development programs. Scientific Expertise Deep expertise in pharmacology and mechanistic biology of biologics, including antibodies, bispecifics, and other engineered protein therapeutics. Strong background in cell biology, including primary cell systems, cytokine biology, receptorligand interactions, signaling pathways, and effector function mechanisms. Extensive experience developing, executing, and troubleshooting in vitro/ex vivo functional assays, such as: Primary immunecell or primarycell functional assays 3D/complex multicomponent cellbased assay systems Signaling pathway and reporterbased assays Cytokine/chemokine readouts (ELISA/MSD) Flow cytometry and highcontent imaging ADCC/CDC or other immuneeffector assays (when relevant) Demonstrated experience advancing biologic drug candidates through key stages of drug development, including target validation, lead optimization, and INDenabling studies, with direct contribution to at least one successful IND submission. Leadership & Interpersonal Skills Proven ability to lead and inspire scientific teams while maintaining high standards of quality and rigor. Excellent communication skills with the ability to translate complex biological data into programrelevant insights. Highly collaborative, strategic, proactive, and adaptable to evolving priorities. Ability to thrive in a dynamic biotech environment and influence across functions. How We Thrive Together: Abscis Core Values We Believe in the Impossible We are one team with one finish line We embrace our differences We deliver Results We do the right thing Innovate because lives depend on it. Compensation and Benefits The salary range for this position is $160,000 -190,000/year. The range provided is based on what we believe is a reasonable estimate for the base salary range for this job at the time of posting. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other jobrelated factors permitted by law. Absci offers highly competitive salaries and benefits, including medical, dental, vision insurance, unlimited vacation, parental leave, employee assistance program, voluntary life and disability insurance, annual bonus potential, and 401(k) with a generous company match. Legal and Equal Employment Opportunity Statement Legal authorization to work in the United States is required. Absci is committed to equal employment opportunity and nondiscrimination for all employees and qualified applicants without regard to a persons race, color, sex, sexual orientation, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, marital status, or any characteristic protected under applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should request the recruiter or hiring manager or contact [email protected]. #J-18808-Ljbffr