Job Title

At AstraZeneca, we pride ourselves on a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation providing opportunities to work across teams, functions and the globe. We support individualized flexibility to balance personal and work commitments while maintaining collaboration in our offices three days a week. Our head office and BlueSky Hub in downtown Toronto are designed for teamwork and strategic collaboration.Our dedication to sustainability is central to our culture and what makes AstraZeneca a great place to work. We act on the health of people, the planet and our business, tackling challenges from climate change to access to healthcare and disease prevention.Introduction to role:Are you ready to lead the charge in transforming patient safety through evidence synthesis? AstraZeneca is seeking a dynamic Safety Evidence Synthesis Manager to join our Safety Epidemiology team. You will conduct targeted and systematic literature reviews, critical appraisals, and AI-assisted evidence synthesis, and help establish best practices across the organization. Your work will drive scientific and operational execution of evidence synthesis and literature reviews that support post-marketing commitments and contextualization projects. You will collaborate with Global Patient Safety, Global Regulatory, Global and Local Medical teams, and R&D to shape strategy, align objectives, and deliver high-quality, decision-ready outputs.AccountabilitiesAuthor and govern protocols: design and write protocols for rapid, scoping, and systematic reviews, as well as meta-analyses, ensuring methodological robustness and alignment with regulatory expectations.Execute and oversee reviews: lead development of search strategies; supervise and perform study screening, data extraction, evidence synthesis, quality/risk of bias assessment, and report writing for patient safetyfocused questions.Deliver ad hoc reviews and appraisals: conduct targeted literature assessments and critical appraisals of published safety studies related to medicinal products and devices; communicate findings with clear implications for pharmacovigilance and risk management.Essential Skills/ExperiencePhD (or equivalent) in epidemiology, public health, or related health science with substantial evidence synthesis experience; or MSc/MPH with extensive expertise in systematic reviews.Hands-on experience planning, conducting, and delivering systematic and ad hoc literature reviews end to end.Advanced skill in critical appraisal of study designs and published literature using established appraisal tools and reporting guidelines.Experience synthesizing, interpreting, and communicating published literature and medical information on drug and patient safety, including adverse event reporting.Desirable Skills/ExperienceStrong commitment to advancing the quality and impact of literature reviews and evidence synthesis in drug safety.Broad knowledge of patient safety, drug safety, epidemiology, and medical terminology.Experience collaborating with internal and external experts, collaborative groups, and contract research organizations (CROs).Annual base salary for this position ranges from $104,103.20 to $136,635.45. AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices are designed to allow colleagues to progress through the salary range over time as they progress in their role. The range in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on skills, experience, and business needs. In some cases, offers outside the range may be considered to address unique circumstances.In addition, permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity and eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.At AstraZeneca you will find a collaborative culture that encourages innovation and values a diverse environment where your contributions matter. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients lives.Ready to lead and encourage? Apply now and take the first step towards an exciting career at AstraZeneca.We are using AI as part of the recruitment process.This advertisement relates to a current vacancy.Great People want to Work with us! Find out why:GTAA Top Employer Award for 11 yearsTop 100 Employers AwardCanadas Most Admired Corporate CultureLearn more about working with us in CanadaView our YouTube channelAre you interested in working at AZ, apply today!AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace free from discrimination. We are committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing .#LI-HybridDate Posted19-Jan-2026Closing Date25-Jan-2026AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with a wide range of perspectives, and we harness industry-leading skills. We welcome and consider applications from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. #J-18808-Ljbffr