Job Description Job Title:Process R & D - Peptide Chemistry Location:Hyderabad, Telangana1.0 Position Summary We are seeking a highly skilled and motivated Research Scientist specializing in peptide chemistry. The ideal candidate will be responsible for the design, execution, optimization, and scale-up of synthetic peptides using both Solid-Phase Peptide Synthesis (SPPS) and Liquid-Phase Peptide Synthesis (LPPS) methodologies. This role requires hands-on expertise in various synthesis techniques, purification, and analytical characterization, as well as a strong commitment to safety, documentation, and project management within a dynamic R&D environment.2.0 Key Responsibilities A. Peptide Synthesis & Development Design and execute multi-step synthesis of complex peptides (up to 30-40 mers) using manual and automated SPPS techniques. Demonstrate expertise with a wide range of peptide synthesis resins (e.g., 2-CTC, Rink Amide, Wang, Sieber) and select appropriate resins, protecting groups (Fmoc/Boc), coupling reagents, and solvents for target sequences. Perform advanced peptide modifications, including disulfide bridging, lactamization, and other cyclization strategies. Conduct peptide synthesis in solution phase (LPPS) utilizing both Fmoc and Boc protection strategies. Expertly carry out critical downstream processes, including resin cleavage, global deprotection, quenching, and product isolation. B. Instrumentation & Technology Operate, troubleshoot, and maintain automated peptide synthesizers. Utilize microwave peptide synthesizers (e.g., CEM Liberty Blue) to optimize reaction conditions and improve synthesis efficiency. Conduct synthesis at various scales using manual peptide reactors (1 L to 10 L). C. Purification & Analysis Purify crude peptides using preparative Reverse-Phase High-Performance Liquid Chromatography (RP−HPLC) and perform subsequent lyophilization. Interpret analytical data (e.g., HPLC, Mass Spectrometry) to assess reaction progress, purity, and yield, and generate trend data to guide process optimization. Conduct comprehensive literature surveys to support the development of novel and efficient synthesis strategies. D. Compliance, Safety & Documentation Maintain meticulous, real-time documentation of all experiments and results in an Electronic Lab Notebook (eLN). Ensure strict adherence to laboratory safety procedures to prevent incidents and maintain a safe working environment. Provide technical support for the technology transfer and execution of peptide manufacturing in GMP plant environments. Ensure timely calibration and proper functioning of laboratory instruments, including analytical balances and pH meters. E. Project Management & Collaboration Effectively plan and execute projects to ensure timely completion and achievement of R&D milestones. Engage in regular interaction and coordination with the Cross-Functional Team (CFT), including Analytical, Quality, and Manufacturing departments.3.0 Qualifications & Experience Education:M.Sc. in Organic Chemistry, Medicinal Chemistry, or a closely related field. Experience:A minimum of 5 to 13 years of direct, hands-on experience in synthetic peptide chemistry within a pharmaceutical or biotechnology industry setting. Proven track record in both SPPS and LPPS is highly desirable. Experience with process scale-up and knowledge of GMP principles is a strong asset.
Job Title
Process R&D - Peptide Chemistry