Job Title

Job Description _Roles & Responsibilities:_ The Guccione Lab at the Icahn School of Medicine at Mount Sinai recently identified that inhibiting spliceosomal assembly through inhibition of arginine methylation provides an effective means of therapeutic splicing inhibition. Specifically, inhibiting either symmetric arginine methylation (mediated by the protein arginine methyltransferase 5 -PRMT5) or asymmetric dimethyl arginine methylation (mediated by type I PRMTs (PRMT1, 3, 4, and 6)) reduces splicing fidelity resulting in strong preferential killing of (i) splicing factor-mutant leukemias and (ii) MYC-overexpressing lymphomas over their wildtype counterparts. In addition the lab is investigating the role of members of the PRDM family of enzymes (e.g. PRDM9, PRDM10, PRDM15), in liver and colorectal cancer. The successful applicant will be part of a highly productive research team studying transcription and post-transcriptional regulation in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics and RNA biology. The successful candidate will be part of a thriving and diverse environment in the Department of Oncological Sciences within the Tisch Cancer Institute. The position offers competitive salary, subsidized postdoc-housing and exposure to a rich environment at Icahn School of Medicine at Mount Sinai and NYC. Requirements: u2022 PhD in molecular biology or similar u2022 Strong background in working with murine tumor models is a plus. u2022 Background in cancer, RNA/chromatin biology and familiarity with recent advances in these fields and NGS technologies is a plus. u2022 Excellent communication skills. Must be able to work as part of a small team and report data clearly. u2022 Proactive and problem-solving attitude is important To apply, please e-mail your CV, research statement, and the names and contact information of three references to: Qualifications . Responsibilities . About Us Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinaiu2019s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time u2014 discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patientsu2019 medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high