Job Title

Job Description The Panagiotakos Lab, in the Departments of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York, is seeking postdoctoral fellows with expertise in calcium imaging, electrophysiology, developmental neuroscience, stem cell biology, and/or genomics/sequencing approaches to study cellular and molecular mechanisms that underlie the acquisition of cell fate during mammalian brain development. Dr. Panagiotakos' team combines multiple complementary approaches, including genetic mouse models, calcium imaging, fluorescence microscopy, pharmacology, cortical slice cultures, and various omics and biochemical analyses, to interrogate roles for ion channels, electrical activity and calcium signaling during normal development and in the context of neuropsychiatric disorders of developmental origin. The qualified candidate will use cutting-edge cellular/molecular biology, imaging and sequencing approaches in these studies, including long-isoform sequencing and live imaging, to investigate the impact of disease-relevant ion channels and calcium signaling on cellular events during brain development, including proliferation, migration and differentiation. Qualifications Basic qualifications: + PhD or MD/PhD in Developmental and Stem Cell Biology, Neuroscience, or Cellular/Molecular Biology; + Demonstrated expertise in cellular/molecular neuroscience, developmental neuroscience, or stem cell biology; + Record of publications in peer-reviewed journals; + Excellent oral and written communication skills; + Ability to work in an international and interdisciplinary team; Experience Required: The postdoctoral candidate must have a Ph.D. degree in the biological sciences (or proof of completion of all Ph.D. requirements prior to starting) with training/experience in developmental neuroscience, neuroscience, and/or stem cell biology and corresponding cellular/molecular biology bench skills. Preference will be given to candidates with a strong record in techniques for studying calcium signaling, including calcium imaging and electrophysiology. Experience in sequencing approaches with relevant bioinformatics skills is a major plus. Non-Bargaining Unit, 859 - Psychiatry - ISM, Icahn School of Medicine Responsibilities Web link to Department: Detail of Research Project: The goals of these studies are to interrogate mechanisms by which intracellular calcium signals link extracellular cues with intrinsic differentiation programs and to elucidate how alternative splicing refines these signals, and to investigate roles for calcium signaling pathways on cortical development. Technical Duties: (include any protocols) + lead independent projects focused on defining cell type specific splice isoforms and calcium signaling mechanisms + technical toolkit will include: long-isoform sequencing, single cell RNA sequencing, genetic mouse models, calcium imaging, bioinformatics analysis, in vivo mouse surgeries, various molecular biology approaches, immunofluorescence staining and microscope + work collaboratively and contribute to mentoring junior lab members + cultivate scientific communication skills by contributing to the writing of grant applications and manuscripts and participating in work in progress meetings and other seminar series