Job Title

Scientist, Small Molecule Synthetic Organic Chemistry Research and DevelopmentExcelsior Sciences of New York is transforming small molecule therapeutic drug discovery with the use of modular chemistry, to make better medicines fast. Excelsior's modular approach leverages smart blocks as the foundation of drug design and synthesis. Our smart blocks and proprietary methodologies enable chemistry that machines can do, rather than building machines that attempt to do chemistry as it is practiced today. Excelsior's operations are fully U.S.-based, as our automated approach enables us to onshore integrated drug discovery. We are seeking a motivated chemist with expertise in synthetic route design and development to support our automated small-molecule discovery platform. The ideal candidate will integrate principles of reaction optimization and high-throughput experimentation to develop robust and reproducible synthetic routes suitable for automation.Key Responsibilitiesu2022In collaboration with cross functional teams (automation engineers, analytical, biology and AI/ML) drive solutions for the development and optimization of reaction conditions for the automated synthesis of small molecules.u2022Develop, troubleshoot, and optimize synthetic routes for generation of complex building blocks.u2022Develop and optimize organic reactions, workups and SPE purifications for automation in HTS fashion.u2022Optimize and test conditions to purify synthesized compounds using solid phase support, including metal scavenging, and develop LC conditions for final product purification.u2022Help design and test protocols for automation system validations.u2022Support continuous automated synthesis of small molecules on HTS fashion.u2022Identify and design synthetic routes for complex building blocks. Guide, troubleshoot and oversee CROs on the synthesis of the compounds, as applicable.u2022Support analytical chemists on chromatographic methods development and analytical equipment troubleshooting.u2022Establish and maintain synthetic chemistry project timeline, and partner with functional leads to coordinate and drive activities. u2022Communicate project status and issues to the management and other stakeholders through meetings and key documents.Qualificationsu2022PhD degree in Organic Chemistry. Postdoctoral experience is preferred but not mandatory.u2022The ideal candidate should have a strong background on synthetic organic chemistry with experience in route scouting and reaction optimization.u2022Strong foundation in transition metal-catalyzed organic reactions is a must. u2022Medicinal chemistry and/or process development experience are an asset.u2022Demonstrated ability to identify challenges and apply creative, data-driven problem-solving approaches to improve chemical processes and workflowsu2022Attention to experimental detail with a proactive mindset to ensure reproducibility, accuracy, and timely completion of deliverables.u2022Ability to work both independently and cross functionally with analytical, automation and biology teams.u2022Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.u2022Ability to consistently generate quality data and experience in using quantitative LC and NMR.u2022Well versed in analytical technology such as LC, NMR, LC-MS, KF, etc. SFC knowledge is a plus.u2022Proficient in purification by column chromatography (manual and automated, such as Biotage or equivalent.u2022Experience with continuous-flow chemistry or high throughput screening is a plus.u2022Automation and AI/ML knowledge is a plus.The salary range for this position is $95,000- $140,000 per year. The actual compensation offered will be based on factors such as relevant experience, education, and skills. In addition to base salary, we offer a comprehensive benefits package, including health insurance, paid time off and other benefits.Excelsior Sciences of New York Is an equal opportunity employer (EEO). We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.Minimum Salary: 95000Maximum Salary: 140000Salary Unit: Yearly