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Job Title


Postdoctoral Fellow-MSH-30035-390


Company : Mount Sinai Health System


Location : New York City, NY


Created : 2026-04-04


Job Type : Full Time


Job Description

Job Description Details of Research Project : How can neuroscience help us design and optimize treatments for devastating disorders of learning and memory? Our lab directly addresses this challenge by leveraging our experimental platform to understand, test, and optimize therapeutic interventions for cognitive disorders. This project focuses on fornix deep brain stimulation (DBS-f)u2014a promising treatment for Alzheimeru2019s disease currently in Phase III clinical trials. The mechanism of this therapy is not known. We will combine DBS-f with our large-scale recording platform to provide a mechanistic, circuit-level explanation for its effects, with the long-term goal of optimizing its clinical application. Technical Duties : (include any protocols) You will be a core driver of our labu2019s scientific mission, leveraging our custom-built research platform to answer fundamental questions about how the brain transforms experience into memory. Beyond the bench, you will have the unique opportunity to bridge the gap between basic research and clinical application through our established network. Your responsibilities will include: u2022 Leading complex experiments using large-scale Neuropixels recordings and patterned microstimulation (DBS) in behaving primates navigating immersive virtual reality environments. u2022 Collaborating directly with world-renowned clinicians and experts in DBS to translate circuit-level findings into frameworks for understanding and treating Alzheimeru2019s disease and related dementias. u2022 Investigating the circuit-level mechanisms of emerging therapies, specifically focusing on the effects of fornix DBS on neural computation. u2022 Mentoring junior lab members and assisting in the development of our growing research team. u2022 Presenting your findings at international conferences (e.g., Gordon Research Conference, Society for Neuroscience) and preparing manuscripts for high-impact publications. Qualifications Educational and other Requirements for the position : u2022 A PhD in Neuroscience, Biomedical Engineering, Psychology, Electrical Engineering, or a related field. u2022 Proficiency in coding (MATLAB or Python) for data acquisition and analysis. u2022 A strong interest in bridging the gap between basic circuit mechanisms and translational applications. Responsibilities Experience Required : u2022 Laboratory experience working in behavioural neuroscience, prefereably with nonhuman primates u2022 Analysis of behavioural and neural datasets u2022 Proficiency in coding (C#, Arduino, bash) Goals/Outcomes of the Research Project : u2022 Mechanistic Understanding: Elucidate the circuit-level mechanisms by which DBS-f alters neural representations in the hippocampus and prefrontal cortex to improve learning and memory. u2022 Therapeutic Optimization: Establish a framework for predicting and explaining the variable efficacy of DBS treatments, paving the way for optimized clinical protocols. u2022 Career Advancement: Produce high-quality datasets leading to first-author publications in top-tier journals and support the fellowu2019s transition to an independent research career. u2022 Technological Innovation: Advance the use of large-scale recording technologies (Neuropixels) combined with neuromodulation in awake, behaving primates About Us Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinaiu2019s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time u2014 discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patientsu2019 medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high