Job Title

POSITION SUMMARYThe Postdoctoral Researcher will investigate mechanisms of brain aging and neurodegenerative disease, with a focus on identifying pathways and small molecules that promote cellular rejuvenation and resilience. This role emphasizes high-throughput screening and cell painting approaches.The successful candidate will demonstrate the potential to lead peer-reviewed publications, contribute innovative experimental strategies, and compete for external fellowships and career development awards.LAB OVERVIEWThe Ellerby lab studies the fundamental mechanisms underlying age-related neurodegenerative diseases and develops therapeutic strategies targeting brain aging. The lab integrates cutting-edge approaches—including induced pluripotent stem cells (iPSCs), genomics, proteomics, high-throughput small-molecule screening, single-cell analysis, and CRISPR/Cas9—to better understand disease biology and identify novel interventions.KEY RESPONSIBILITIESDesign and implement high-throughput screening strategies to identify small molecules that promote cellular resilience or reverse aging phenotypes, with a focus on OXR1 and APOE2 biology.Conduct high-content imaging experiments and quantitative image analysis.Develop and optimize high-throughput screening (HTS) workflows.Apply organoid and advanced in vitro model systems to study neurodegeneration.Operate and integrate complex robotic and multi-instrument platforms.Collaborate with interdisciplinary teams at the Buck Institute to develop standardized protocols and experimental designs.Analyze large-scale imaging and multi-omics datasets using Python and/or R.Perform data integration, annotation, and visualization using appropriate computational tools.Present findings at lab meetings, institutional seminars, and scientific conferences.QUALIFICATIONSEducationPhD in Neuroscience, Biology, Chemistry, or a related field Experience and SkillsStrong cell culture expertiseExperience with iPSC systems (preferred)Background in stem cell biology, neurodegenerative disease, and/or CRISPR/Cas9 technologiesDemonstrated track record of first-author or lead-author publicationsExperience with high-throughput or high-content screening approaches (preferred)Proficiency in data analysis using Python, R, or similar toolsAbility to work both independently and collaboratively in an interdisciplinary environmentCOMPENSATION & BENEFITSSalary Range: $73,760-81,440 annually, commensurate with experience and qualificationsComprehensive benefits package including health insurance, paid parental leave, childcare assistance, generous paid time off, and a 401(k) with 5% employer matchAccess to state-of-the-art research facilities and technologiesCollaborative and mission-driven scientific environmentABOUT USThe Buck Institute is dedicated to extending human healthspan by addressing the biological mechanisms of aging. As a leading independent non-profit research institute in Marin County, CA, the Buck brings together experts across multiple disciplines to prevent or delay age-related diseases, including Alzheimers disease, Parkinsons disease, cancer, cardiovascular disease, and diabetes.The Buck Institute is an equal opportunity employer committed to fostering a diverse and inclusive workplace. We strongly encourage applicants who will contribute to the diversity of our community.TO APPLYPlease submit your Curriculum vitae (CV), a cover letter describing your research interests and career goals, and contact information for 2 references. For Additional Information:Professor Lisa M. Ellerby, Ph.D.